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CIAC101

CIAC101 is an effective TLR4 inhibitor that can cross the blood-brain barrier, with an IC50 of 17.0 nM. It blocks Lipopolysaccharides (LPS) -induced NF-κB activation and reduces the expression of pro-inflammatory mediators (iNOS, IL-1β, TNF-α, and IL-6) . CIAC101 exhibits potent anti-neuroinflammatory activity and counters drug-induced neurobehavioral adaptations, making it useful for research on addiction and neurological disorders.

Product Specifications

Storage Conditions

-20°C

Notes

For research use only.

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