XSJ151
XSJ151 is a topoisomerase I inhibitor that stabilizes the DNA-topoisomerase I covalent complex, inducing DNA double-strand breaks. The DNA damage caused by XSJ151 activates the p53-p21 signaling pathway, specifically regulating the expression of cyclins, resulting in G2/M phase cell cycle arrest. Additionally, it disrupts the dynamic equilibrium of Bcl-2 family proteins, thereby triggering apoptosis in gastric cancer cells. XSJ151 is applicable for research in gastric cancer.
Product Specifications
CAS Number
1685279-23-5
Smiles
O (C (CN=C (CC1=CC=C (OC) C=C1) NS (=O) (=O) C2=CC=C (N (=O) =O) C=C2) =O) [C@@]3 (CC) C4=C (C (=O) N5C (=C4) C=6C (C5) =CC=7C (N6) =CC=CC7) COC3=O
Molecular Formula
C37H31N5O10S
Molecular Weight
737.74
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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