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LY456236 free base

LY456236 free base is a selective, non-competitive, orally active antagonist of the glutamate receptor 1 (mGlu1), effectively inhibiting phosphoinositide hydrolysis with an IC50 of 0.145 μM. Additionally, it inhibits EGFR with an IC50 of 0.918 μM. By suppressing the MAPK pathway, LY456236 free base blocks cell proliferation and counters the anti-apoptotic effects of DHPG. This compound is useful for seizure research.

Product Specifications

CAS Number

338738-57-1

Smiles

N=1C=NC (NC2=CC=C (OC) C=C2) =C3C=C (OC) C=CC13

Molecular Formula

C16H15N3O2

Molecular Weight

281.32

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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