GSK3β-IN-4
GSK3β-IN-4 is a selective, potent, orally active ATP-competitive inhibitor of GSK3β, with an IC50 value of 0.37 nM. It also inhibits GSK3α with an IC50 of 2.75 nM and a selectivity index (SI) of 7.4. By inhibiting GSK3β, GSK3β-IN-4 reduces tau protein phosphorylation at the Ser396 site and improves cognitive deficits in Alzheimer's disease models. This compound is applicable for Alzheimer's research.
Product Specifications
CAS Number
3083425-61-7
Smiles
N (C (=O) C1CCCC1) C2=C3C (C=4C (N3) =CC (C (N[C@H] (C) C5=CC=CC=C5) =O) =CC4) =CC=N2
Molecular Formula
C26H26N4O2
Molecular Weight
426.52
Storage Conditions
-20°C
Notes
For research use only.
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