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LY3295668 erbumine

LY3295668 (AK-01) erbumine is a highly selective, orally active inhibitor of Aurora-A kinase, with Ki values of 0.8 nM for AurA and 1038 nM for AurB. It effectively suppresses AurA autophosphorylation, inducing mitotic arrest and apoptosis (apoptosis), while preventing polyploidy associated with AurB inhibition. LY3295668 erbumine is applicable for studying small cell lung cancer.

Product Specifications

CAS Number

1919888-07-5

Smiles

C (C) (C) (C) N.C ([C@]1 (C (O) =O) C[C@@H] (C) N (CC2=C (F) C (Cl) =CC=C2) CC1) C=3N=C (NC4=NNC (C) =C4) C=CC3F

Molecular Formula

C28H37ClF2N6O2

Molecular Weight

563.09

Storage Conditions

-20°C

Notes

For research use only.

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