FGFR4-IN-24
FGFR4-IN-24 is a selective irreversible covalent inhibitor of FGFR4 with an IC50 of 1.2 nM. It demonstrates significantly weaker activity against the other three FGFR family kinases (FGFR1-3) . FGFR4-IN-24 effectively inhibits the FGF19/FGFR4 signaling pathway, suppressing the proliferation of the HuH-7 hepatocellular carcinoma cell line (GI50= 17 nM) . In HuH-7 mouse xenograft models, FGFR4-IN-24 shows notable antitumor activity. This compound is applicable for hepatocellular carcinoma research.
Product Specifications
CAS Number
3053546-73-6
Smiles
O=C (C=C) NC=1C=CC=CC1NC2=NC=3NC=C (C (=O) C4=CC (=CC=C4F) C (=O) NC5CC5) C3C=C2
Molecular Formula
C27H22FN5O3
Molecular Weight
483.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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