FGFR4-IN-24

FGFR4-IN-24 is a selective irreversible covalent inhibitor of FGFR4 with an IC50 of 1.2 nM. It demonstrates significantly weaker activity against the other three FGFR family kinases (FGFR1-3) . FGFR4-IN-24 effectively inhibits the FGF19/FGFR4 signaling pathway, suppressing the proliferation of the HuH-7 hepatocellular carcinoma cell line (GI50= 17 nM) . In HuH-7 mouse xenograft models, FGFR4-IN-24 shows notable antitumor activity. This compound is applicable for hepatocellular carcinoma research.