MMP-2/9-IN-2

MMP-2/9-IN-2 (Compound 6k) functions as an inhibitor of MMP-2 and MMP-9, with IC50 values of 29.27 μM and 24.87 μM, respectively. It exhibits selective toxicity against various human liver cancer cell lines and induces cell cycle arrest and apoptosis (apoptosis), significantly inhibiting cell migration and invasion. Additionally, MMP-2/9-IN-2 suppresses the phosphorylation of the STAT3 signaling pathway and demonstrates potent antitumor activity in a nude mouse xenograft model with HepG2 liver cancer cells.