PDE/TRPA1/CHIT1-IN-1

PDE/TRPA1/CHIT1-IN-1 is an inhibitor of PDEs, TRPA1, and hCHIT1 with a KD value of 37.7 μM. It acts as a broad-spectrum PDE inhibitor, effectively targeting key subtypes including PDE4B, PDE7A, PDE3A, and PDE8A with IC50 values of 15.54, 15.15, 8.39, and 16.46 μM, respectively. By inhibiting NLRP3 inflammasome activation and blocking NF-κB phosphorylation, PDE/TRPA1/CHIT1-IN-1 downregulates the expression of pro-inflammatory genes (TNF-α and IL-6) in vivo. This compound is useful for research into chronic obstructive pulmonary disease (COPD) and related inflammatory lung conditions.