SARS-CoV-2 nsp14-IN-10

SARS-CoV-2 nsp14-IN-10 is a highly effective and selective inhibitor of the NSP14 (IC50 = 0.34 μM) S-adenosylmethionine (SAM) binding pocket. This compound exhibits significant antiviral activity against SARS-CoV-2 and has broad-spectrum efficacy against other β-coronaviruses. It inhibits the replication phase of SARS-CoV-2 and also suppresses viral translation while stimulating immune responses. Additionally, SARS-CoV-2 nsp14-IN-10 can specifically reverse NSP14-mediated alterations in the host transcriptome. It is a valuable compound for research on SARS-CoV-2.