BMS 275183

BMS 275183 is a potent, orally active analogue of Paclitaxel. It stabilizes microtubules and exhibits antitumor activity in in vivo tumor models. BMS 275183 is also effective in vitro against Paclitaxel-resistant tumors, including those with tubulin mutations or overexpression of P-glycoprotein. It is applicable in cancer research, such as in non-small cell lung cancer (NSCLC) and prostate cancer studies.

Product Specifications

CAS Number

355113-98-3

Smiles

O (C (OC) =O) [C@]12[C@]3 ([C@H] (OC (=O) C4=CC=CC=C4) [C@@]5 (O) C (C) (C) C ([C@@H] (OC (C) =O) C (=O) [C@]3 (C) [C@@H] (O) C[C@]1 (OC2) [H]) =C (C) [C@@H] (OC ([C@@H] ([C@@H] (NC (OC (C) (C) C) =O) C (C) (C) C) O) =O) C5) [H]