SERCA2a activator 2

SERCA2a activator 2 (Compound 25) is a potent activator of SERCA2a (cardiac type) and also activates SERCA1a (skeletal muscle type) . Under [Ca2+]MAX conditions, it enhances SERCA2a ATPase activity and facilitates Ca2+ uptake with EC50 values of 4 μM and 0.80 μM, respectively. It consistently activates under near-physiological [Ca2+]MID conditions as well. Furthermore, SERCA2a activator 2 exhibits low cytotoxicity, making it useful for researching diseases such as heart failure.