(E) -Belizatinib
(E) -Belizatinib ((E) -TSR-011) (compound 36) is the (E) -isomer of Belizatinib, and serves as a potent, highly selective, and orally active inhibitor of anaplastic lymphoma kinase (ALK), with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. The compound exhibits over 61-fold selectivity against JAK2, SRC, and IGF1R, and demonstrates excellent efficacy and pharmacokinetic properties in rats and dogs. (E) -Belizatinib is applicable for research in ALK-driven cancers.
Product Specifications
CAS Number
1388225-72-6
Smiles
N (\C (=O) C1=CC=C (F) C=C1) =C\2/N (C=3C (N2) =CC=C (CN4CCC (C (C) (C) O) CC4) C3) [C@H]5CC[C@@H] (C (NC (C) C) =O) CC5
Molecular Formula
C33H44FN5O3
Molecular Weight
577.75
Storage Conditions
-20°C
Notes
For research use only.
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