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XRF-1021

XRF-1021 is an orally active HIPK2 inhibitor with an IC50 value of 0.18 μM. It reduces the expression of fibrosis markers such as fibronectin, type I collagen, and α-SMA in NRK-49F and HK-2 cells stimulated by TGF-β1. XRF-1021 blocks signaling pathways including TGF-β, NF-κB, p53, Wnt/β-catenin, and Notch. Additionally, it alleviates renal injury and fibrosis in vivo and can be utilized for research in chronic kidney disease.

Product Specifications

CAS Number

2968523-32-0

Smiles

FC1=CN=C (N=C1NC2=CC=C (C=C2) N3CCNCC3) N4C (=NC=5C=CC=CC54) N

Molecular Formula

C21H21FN8

Molecular Weight

404.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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