α5β1 integrin-IN-1
α5β1integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. Its selectivity for α5β1 is over 10,000 times greater than for αVβ3 (pIC50 of 5.5) . This compound reduces airway smooth muscle (ASM) tension by disrupting intercellular connections. In rodents, α5β1integrin-IN-1 demonstrates excellent inhalation pharmacokinetic properties and is applicable in asthma research.
Product Specifications
CAS Number
2649899-08-9
Smiles
C (N[C@@H] (CNC (CNC (=O) C1=CC (NC=2NCC (F) CN2) =CC=C1) =O) C (O) =O) (=O) C3=C (Cl) C=C (C=C3Cl) C4=CC=CC=C4
Molecular Formula
C29H27Cl2FN6O5
Molecular Weight
629.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
