INVA8001
INVA8001 is a highly selective and orally active chymase inhibitor, with IC50 values of 0.02 μM for human chymase and 0.03 μM for mouse mast cell protease 4 (mMCP-4) . It exhibits IC50 values of 3.4 μM for bovine α-chymotrypsin and 32.1 μM for human cathepsin G, demonstrating over 1000-fold selectivity against other related serine proteases. In a mouse model of primary sclerosing cholangitis (PSC), INVA8001 inhibits mast cell activity, improves biliary pathology, alleviates cholestasis, and displays anti-inflammatory and anti-fibrotic properties.
Product Specifications
CAS Number
1312993-34-2
Smiles
C (C) (O) =O.C (C1=C (OC) C=CC (Cl) =C1) [C@@H]2C (=O) N (C (N[C@H] (CCC) C3=CC (N) =C (C (O) =O) C=C3) =O) C\C (=N\OCC) \NC2
Molecular Formula
C29H38ClN5O8
Molecular Weight
620.1
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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