Docarpamine

Docarpamine is an orally active dopamine prodrug that is converted into active dopamine in the small intestine and liver through hydroxylation. In situations of spontaneous hypertension, it primarily activates peripheral D1-like receptors (D1-like receptor) to lower blood pressure and heart rate. Under normal blood pressure conditions, Docarpamine exhibits pressor effects and tachycardia by activating D1-like receptors, vasopressin V1 receptors (vasopressin V1 receptor), and α-adrenergic receptors (α-adrenergic receptor) . Docarpamine is useful for studying renal vasodilation and diuresis.