JAK2-IN-18
JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. It effectively inhibits the JAK-STAT signaling pathway, with an IC50 value of less than 100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 suppresses the proliferation of abnormally proliferating myeloid cells and is useful in research on myeloproliferative disorders, such as essential thrombocythemia.
Product Specifications
CAS Number
3108318-77-7
Smiles
O=C (C=1N=C (C=CC1) CN2C (=O) C3=CC=C (C=C3C4 (C2) CC4) C=5C=CC=C (NC6=CC (=NN7C=CN=C67) NC (=O) C8CC8) C5OC) N (C) C
Molecular Formula
C37H36N8O4
Molecular Weight
656.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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