SH543

SH543 is a potent anti-osteoporosis agent that inhibits RANKL-induced osteoclastogenesis, with an IC50 value of 3.3 nM. It directly binds to KEAP1, activating the Nrf2-HO-1 antioxidant pathway, reducing reactive oxygen species (ROS) levels, and inhibiting PI3K-AKT and MAPK signaling pathways. SH543 alleviates pathological bone loss in ovariectomized mice and is useful for osteoporosis research.