DPP9-IN-2
DPP9-IN-2 is a selective and potent orally active inhibitor of dipeptidyl peptidase 9 (DPP9), with an IC50 value of 12.9 nM. It exhibits a selectivity index of 59 for DPP8 and shows no significant inhibitory activity on related peptidases, including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce pyroptosis in cancer cells and demonstrates modest synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitors. This compound is applicable for research in cancer and infection.
Product Specifications
CAS Number
3020859-44-0
Smiles
O=C (NC12CC3CC (C1) CC (NCC (=O) N4CC5=CC=C (F) C=C5C4) (C3) C2) C6=CC=C (C=C6) C=7C=CC (F) =CC7
Molecular Formula
C33H33F2N3O2
Molecular Weight
541.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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