GRK5-IN-5
GRK5-IN-5 (Compound 4a) is a selective inhibitor of G protein-coupled receptor kinase 5 (GRK5) with an IC50 value of 0.03 μM. It shows an IC50 of 2.2 μM for GRK2 and 0.036 μM for GRK6. GRK5-IN-5 exhibits potent anti-hypertrophic activity in cardiac muscle and inhibits the proliferation of non-cardiac cells. It blocks pathological cardiac remodeling by inhibiting the abnormal upregulation of hypertrophic marker genes Nppa and Nppb. GRK5-IN-5 is useful for research in myocardial hypertrophy.
Product Specifications
CAS Number
3061801-11-1
Smiles
C (=C\1/C=2C (NC1=O) =CC=C (C (N[C@H] (C) C3=CC=C (F) C=C3) =O) C2) \C4=C (C) C (NC ([C@@H] (O) C5=CC=CO5) =O) =C (C) N4
Molecular Formula
C30H27FN4O5
Molecular Weight
542.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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