Keap1/Nrf2/ARE activator 2

Keap1/Nrf2/ARE activator 2 is an activator of the Keap1/Nrf2/ARE pathway, acting as a non-competitive inhibitor of AChE with an IC50 of 14.79 μM and a Ki of 1.35 μM. It enhances Nrf2 nuclear translocation, thereby upregulating antioxidant gene expression and boosting cellular defenses against oxidative stress. In PC12 cells, Keap1/Nrf2/ARE activator 2 demonstrates significant neuroprotective effects against damage induced by H2O2 and Scopolamine (SCA) . In zebrafish models, it alleviates cognitive deficits and neuroinflammation associated with SCA-induced impairments. This compound is relevant for Alzheimer's disease research.