Mu opioid receptor antagonist 9

Muopioid receptor antagonist9 is a potent and highly selective μ-opioid receptor (MOR) antagonist with the ability to cross the blood-brain barrier, having a Ki value of 77.3 nM. It exhibits selectivity for the κ-opioid receptor (KOR) and δ-opioid receptor (DOR) . This compound effectively blocks the analgesic effects of psychoactive substances and can reverse respiration depression induced by these substances in mice. Additionally, Muopioid receptor antagonist9 is applicable for research on opioid use disorder (OUD) .