TTK-IN-5

TTK-IN-5 is an orally active and selective covalent threonine tyrosine kinase (TTK) inhibitor with an IC50 of 8.918 nM. It demonstrates antiproliferative activity against several cell lines, including MDA-MB-231, A2780, HCT116, HCC1569, and MKN1, with IC50 values of 0.113 μM, 0.476 μM, 3.136 μM, 3.649 μM, and 1.856 μM, respectively. In xenograft mouse models using A2780 and MDA-MB-231, TTK-IN-5 effectively inhibits tumor growth without significant toxicity. TTK-IN-5 is applicable in research on cancers such as breast and ovarian cancer.