ACI-19278
ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. It selectively binds to pathological TDP-43 aggregates without cross-reactivity to proteins such as Aβ and Tau. Using positron emission tomography ([18F]ACI-19278), this compound has successfully visualized TDP-43 pathology in the human brain. ACI-19278 is suitable for in vivo diagnostic research of TDP-43 protein pathologies.
Product Specifications
CAS Number
3033951-64-0
Smiles
FC1=C (C=2SC3=C (N2) CCN (C3=O) C=4C=CC=NC4) C=CC (=N1) N5CC[C@@H] (F) C5
Molecular Formula
C20H17F2N5OS
Molecular Weight
413.45
Storage Conditions
-20°C
Notes
For research use only.
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