TLR2/9 antagonist 1
TLR2/9 antagonist 1 (Compound 24) is a reversible covalent antagonist of TLR2, with an IC50 of 0.5 μM for TLR2/TLR6 and 0.6 μM for TLR2/TLR1, as well as TLR9, with an IC50 of 0.32 μM. This compound does not significantly affect other TLR subtypes and is utilized for studying central nervous system diseases and malignancies caused by inflammation.
Product Specifications
CAS Number
2377679-85-9
Smiles
C (=C/C1=CC (C=O) =C (O) C (F) =C1) \C2=CC=C (C=C2) N3CCCC3
Molecular Formula
C19H18FNO2
Molecular Weight
311.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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