Cyclic ADP-​ribose diammonium

Cyclic ADP-ribose diammonium (cADPR diammonium) serves as a potent calcium mobilization second messenger, synthesized from NAD+ by ADP-ribosyl cyclase. It primarily enhances cytosolic calcium levels by triggering release from the endoplasmic reticulum via Ryanodine receptors, and by facilitating extracellular influx through TRPM2 channels.