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NAE-IN-3

NAE-IN-3 (compound 1) is a potent and highly selective non-covalent competitive inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 0.8 μM. It inhibits NAE by blocking the ATP binding site and demonstrates selectivity over related E1 enzymes UAE and SAE. NAE-IN-3 is applicable for cancer research.

Product Specifications

CAS Number

951950-33-7

Smiles

O=C (O) CNC (=O) CNC (=O) COC=1C=CC=2N=C3N (C (=O) C2C1) CCC3

Molecular Formula

C17H18N4O6

Molecular Weight

374.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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