Tubulin-IN-62

Tubulin-IN-62 is a potent tubulin inhibitor targeting the colchicine binding site. It has an IC50 of 17.2 nM in SKOV3 cells and 19.3 nM in HCC827 cells. Tubulin-IN-62 inhibits microtubule polymerization, arrests the cell cycle at the G2/M phase, and induces apoptosis. In xenograft tumor models, it demonstrates significant antitumor efficacy with good tolerability. Tubulin-IN-62 is applicable for research on ovarian cancer and non-small cell lung cancer.