NLRP3-IN-85

NLRP3-IN-85 (compound 5d) is a potent inhibitor of NLRP3 that operates independently of mitochondrial membrane potential (ΔΨm) . It protects mitochondria from oxidative stress and inflammatory damage while inhibiting key inflammatory factors (NO, TNF-α, IL-6) . NLRP3-IN-85 alleviates acute lung injury in mice and reduces paw edema in rats, making it useful for acute lung injury (ALI) research.