PLAGL2-IN-1

PLAGL2-IN-1 is an inhibitor of pleomorphic adenoma gene-like 2 (PLAGL2) with a dissociation constant (Kd) of 2.23 μM. This compound suppresses the transcriptional activity of PLAGL2, induces G0/G1 cell cycle arrest and apoptosis, thereby inhibiting the proliferation of hepatocellular carcinoma (HCC) cells. It disrupts extracellular matrix structure and inhibits the PI3K-AKT signaling pathway by reducing AKT phosphorylation levels. Additionally, PLAGL2-IN-1 inhibits tumor growth in HCCLM3 xenograft mouse models and is applicable for research in hepatocellular carcinoma.