DL78

DL78 is a potent antimitotic agent that induces mitotic arrest, mitotic catastrophe, and apoptosis in cancer cells by disrupting the interaction between Myc and α-tubulin. It exhibits broad anticancer activity, particularly targeting cancer cells characterized by chromosomal instability and MYC overexpression. In the OV81.2 xenograft model, DL78 significantly reduces tumor burden. DL78 can be employed in ovarian cancer research.