Nitromemantine
Nitromemantine (NitroSynapsin) is a nitrate ester derivative of Memantine and acts as a bifunctional NMDAR antagonist. It demonstrates significant efficacy in rodent models of cerebral infarction through a dual mechanism of open channel blockade and NO/redox modulation of receptors. Under hypoxic conditions, Nitromemantine specifically targets ischemic neurons, enhancing its activity. It inhibits NMDA-induced currents with an IC50 of 2.4 μM and is utilized in the study of ischemic stroke.
Product Specifications
CAS Number
765890-91-3
Smiles
O=N (=O) OC12CC3 (N) CC (CC) (C1) CC (CC) (C2) C3
Molecular Formula
C14H24N2O3
Molecular Weight
268.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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