IMQT_020

IMQT_020 is a selective allosteric SLC1A5_var inhibitor. It disrupts the trimer assembly of SLC1A5_var, leading to a metabolic crisis in cancer cells and selectively inhibiting their growth. iMQT_020 reduces compensatory glutamine metabolism and oxidative phosphorylation, causing widespread metabolic disruption in cancer cells. It lowers GSH levels while increasing intracellular and mitochondrial ROS levels. Additionally, iMQT_020 induces apoptosis and ferroptosis and upregulates PD-L1 expression through epigenetic mechanisms. This compound is applicable in research on pancreatic, lung, and colon cancers.