(S) - (-) -Felodipine

(S) - (-) -Felodipine is the S-enantiomer of Felodipine and functions as an antihypertensive agent. As a derivative of 1,4-dihydropyridine, it acts as a vascular-selective calcium channel blocker. Felodipine inhibits activation of vascular effector cells and disrupts the contraction process in vitro. In canine models, it reduces mean arterial blood pressure by 20%. (S) - (-) -Felodipine exhibits a high metabolic rate in rat and canine liver microsomes.