Benzo-17R-RvD2

Benzo-17R-RvD2 is a benzo analog of RvD2 that enhances phagocytosis in human macrophages, limits neutrophil infiltration, lowers TNF-α levels, and increases the activity of IL-1 receptor antagonists during peritonitis. It promotes human leukocyte E. coli killing and reduces neutrophil aggregation area without affecting anti-Candida activity. Benzo-17R-RvD2 activates the human RvD2 receptor with an EC50 of approximately 1.5 nM. This compound is applicable in the research of inflammation-related diseases, including cardiovascular diseases, cancer, neuroinflammation, pain, and muscle regeneration.