Ironomycin
Ironomycin is a derivative of Salinomycin. It exhibits selective inhibitory activity against mantle cell lymphoma (MCL) cells. Ironomycin halts the cell cycle and induces apoptosis and ferroptosis. It also causes DNA double-strand breaks and activates the unfolded protein response (UPR), specifically accumulating the IRE1α signaling pathway. Combined use of Ironomycin and Ibrutinib shows a synergistic effect. Ironomycin is useful for MCL research.
Product Specifications
CAS Number
1884647-72-6
Smiles
N (CC#C) [C@H]1[C@]2 (O[C@@]3 (O[C@] ([C@H] (C ([C@H] ([C@H] ([C@H] (C) [C@@]4 (O[C@@] ([C@H] (C (O) =O) CC) (CC[C@@H]4C) [H]) [H]) O) C) =O) CC) ([C@@H] (C) C[C@H]3C) [H]) C=C1) O[C@@] (C) (CC2) [C@@]5 (O[C@@H] (C) [C@] (CC) (O) CC5) [H]
Molecular Formula
C45H73NO10
Molecular Weight
788.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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