Antifungal agent 144

Antifungalagent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with a minimum inhibitory concentration (MIC) of 7.5 μg/mL. It simultaneously inhibits chitin deacetylase (chitin deacetylase AngCDA) and 1,3-β-glucan synthase (1,3-β-glucan synthase) . The compound functions by disrupting the integrity of the fungal cell wall and does not bind to ergosterol. Additionally, Antifungalagent 144 is useful in studying Aspergillus niger infections.