2DG-ODDA

2DG-ODDA is a potent antitumor derivative of 2-deoxyglucose (2-DG) . It induces apoptosis and reduces ATP production. 2DG-ODDA is absorbed via fatty acid and glucose transporters and cleaved by α-Mannosidase to release 2DG, thereby inhibiting N-glycosylation and disrupting cellular metabolism. It suppresses tumor growth in 4T1 murine models and is applicable in triple-negative breast cancer (TNBC) research.