Glutaminase C-IN-3

GlutaminaseC-IN-3 is a potent allosteric inhibitor of glutaminase C (GAC) with an EC50 of 116 nM. It modulates cellular metabolites and elevates reactive oxygen species (ROS) production by inhibiting glutamine metabolism. In A549 xenograft mouse models, GlutaminaseC-IN-3 demonstrates significant antitumor activity. This compound is applicable for research on non-small cell lung cancer (NSCLC) .