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VHL Ligand 38

VHL Ligand 38 (Compound 1) is a competitive inhibitor of the E3 ubiquitin ligase VHL, demonstrating IC50 values of 4.1 μM and 7.0 μM in 1% and 10% DMSO solutions, respectively. It features a hydroxyproline residue and an isoxazole acetamide moiety, and effectively inhibits the binding of the fluorescence peptide derived from HIF1α (FAM-DEALA-Hyp-YIPD) to VHL.

Product Specifications

CAS Number

1360616-29-0

Smiles

C (CC=1ON=C (C) C1) (=O) N2[C@H] (C (NCC3=CC=C (C=C3) C4=CN=CO4) =O) C[C@@H] (O) C2

Molecular Formula

C21H22N4O5

Molecular Weight

410.43

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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