Nafenodone

Nafenodone is an antidepressant that decreases the frequency and amplitude of contractions while prolonging the recovery time of the sinoatrial node. In isolated rat vascular smooth muscle, Nafenodone inhibits spontaneous mechanical activity in the portal vein segments with an IC50 value of 1.4 μM. It also relaxes contractions induced by high concentrations of K+ and norepinephrine.