COX-2-IN-63

COX-2-IN-63 (Compound 6k) is an orally active COX-2 inhibitor with an IC50 of 0.89 μM. It reduces levels of inflammatory mediators PGE2, TNF-α, and IL-6. In a rat paw edema model, COX-2-IN-63 effectively alleviates acute inflammation with a lower risk of gastrointestinal side effects. This compound is suitable for anti-inflammatory research.