CDK2-IN-51
CDK2-IN-51 is a pyrazolopyridine derivative and acts as a CDK2 inhibitor with an IC50 of 23.47 nM. It reduces the expression of DNA replication factors (Polα, MCM7, ORC2, and ORC4) and causes cell cycle arrest before the G1 phase. CDK2-IN-51 does not induce apoptosis and does not significantly affect CDK2 protein expression. This compound is applicable in colorectal cancer research.
Product Specifications
CAS Number
1443-10-3
Smiles
N=1C2=NN3C (N=C (C=C3C) C) =C2C (=CC1C) C=4C=CC=CC4
Molecular Formula
C18H16N4
Molecular Weight
288.35
Storage Conditions
-20°C
Notes
For research use only.
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