Immunoproteasome-IN-2

Immunoproteasome-IN-2 is a selective immunoproteasome inhibitor with an IC50 of 232.3 nM for the LMP7 subunit and 9384.9 nM for the β5 subunit. It additionally displays inhibitory activity against LMP2 and MECL-1 subunits. In an arthritis mouse model, Immunoproteasome-IN-2 demonstrates anti-inflammatory effects and shows low hepatotoxicity and hematotoxicity in toxicology studies, linking its LMP7/β5 selectivity to reduced systemic toxicity. Immunoproteasome-IN-2 can be utilized in arthritis-related research.