CC-11

CC-11 is an orally bioavailable small molecule drug conjugate (SMDC) that links a PI3K/mTOR inhibitor to an extracellular heat shock protein 90 (EHSP90) targeting ligand via a cleavable linker. It exhibits strong binding activity to HSP90 (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM) . CC-11 shows antiproliferative effects against colon cancer cells and demonstrates significant efficacy in the HCT-116 xenograft model. It is applicable in colon cancer research.