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H111-H7

H111-H7 is an inhibitor of the E3 ubiquitin ligase 27 containing the WW domain (WWP2), with a KD value of 717 nM. In a unilateral ischemia-reperfusion (UIR) mouse model, H111-H7 inhibits the expression of WWP2, restores the level of succinate dehydrogenase complex subunit C (SDHC), and slows the progression from acute kidney injury (AKI) to chronic kidney disease (CKD) . H111-H7 is applicable for studying the transition from AKI to CKD.

Product Specifications

CAS Number

220965-54-8

Smiles

O=C (C=1SC (SCC2=CC=C (Cl) C=C2) =C (C1) N (=O) =O) C

Molecular Formula

C13H10ClNO3S2

Molecular Weight

327.8

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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