H111-H7
H111-H7 is an inhibitor of the E3 ubiquitin ligase 27 containing the WW domain (WWP2), with a KD value of 717 nM. In a unilateral ischemia-reperfusion (UIR) mouse model, H111-H7 inhibits the expression of WWP2, restores the level of succinate dehydrogenase complex subunit C (SDHC), and slows the progression from acute kidney injury (AKI) to chronic kidney disease (CKD) . H111-H7 is applicable for studying the transition from AKI to CKD.
Product Specifications
CAS Number
220965-54-8
Smiles
O=C (C=1SC (SCC2=CC=C (Cl) C=C2) =C (C1) N (=O) =O) C
Molecular Formula
C13H10ClNO3S2
Molecular Weight
327.8
Storage Conditions
-20°C
Notes
For research use only.
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