M3 mAChR agonist 1

M3mAChRagonist 1 is a dual positive allosteric modulator (PAM) that primarily targets the M3 subtype of M3/M5 mAChRs. It demonstrates high subtype selectivity over other mAChR subtypes, including M1, M2, and M4. By modulating the M3 muscarinic acetylcholine receptor, M3mAChRagonist 1 enhances the signaling pathway, leading to increased contraction of isolated rat bladder strips.