Cbl-b-IN-30

Cbl-b-IN-30 is an orally active inhibitor of Casitas B-lineage lymphoma-b (CBLB) . It specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity, with an IC50 value of 9.1 nM. Cbl-b-IN-30 promotes IL-2 secretion (EC50 value of 187.5 nM) and enhances T cell activation. This compound also exhibits antitumor activity and can induce immune memory. It is useful for colon cancer research.